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三木 卓幸

特任講師 東京大学工学系研究科 化学生命工学専攻


東京都文京区 本郷7−3−1 


About Me

Takayuki Miki received his Ph.D. in 2016 from Kyoto University under the supervision of Prof. Itaru Hamachi. He worked for JSR corporation from 2016 to 2018. In 2018, he moved to School of Life Science and Technology, Tokyo Institute of Technology, and became an Assistant Professor. In 2023, he was specially appointed as Project Lecturer of the University of Tokyo.  His research interests include (1) protein modification, (2) conditional proteomics, and (3) peptide/protein engineering.


June 2022 – Present

Dec. 2020 – Present

Sep. 2017 – Mar. 2018

Assitant Professor, School of Engineering, The University of Tokyo

​Tenured Research Scientist, RIKEN Center for Emergent Matter Science (CEMS)

JSPS Research Fellow (PD)

Aug. 2016 – Nov. 2016

Research Intern, BASF GM/IA, Scouting and Open Research Center Asia Pacific

Selected Publications

Takayuki Miki*, Keigo Namii, Kenta Seko, Shota Kakehi, Goshi Moro and Hisakazu Mihara, Pattern enrichment analysis for phage selection of stapled peptide ligands. Chem. Sci. 2022, 13, 12634–12642 (Front Cover, selected as Chem Sci Pick, Corresponding author)


Takayuki Miki*, Keigo Kajiwara, Sae Nakayama, Masahiro Hashimoto and Hisakazu Mihara, Effects of hydrophobic residues on the intracellular self-assembly of de novo designed peptide tags and their orthogonality. ACS Synth. Biol. 2022, 11, 2144–2153 (Front Cover, Corresponding author)


Takayuki Miki*, Masahiro Hashimoto, Taichi Nakai and Hisakazu Mihara, A guide-tag system controlling client enrichment into Y15 peptide-based granules for an in-cell protein recruitment assay. Chem. Commun. 2021, 57, 11338 (Corresponding author)


Takayuki Miki*, Taichi Nakai, Masahiro Hashimoto, Keigo Kajiwara, Hiroshi Tsutsumi and Hisakazu Mihara, Intracellular artificial supramolecules based on de novo designed Y15 peptides. Nat. Commun. 2021, 12, 3412 (Editors Highlight, Corresponding author) 


Takayuki Miki, Masashi Awa, Yuki Nishikawa, Shigeki Kiyonaka, Masaki Wakabayashi, Yasushi Ishihama and Itaru Hamachi*, A conditional proteomics approach to identify proteins involved in zinc homeostasis. Nat. Methods 2016, 13, 931–937. (Highlighted by Nat. Methods and Nat. Chem. Biol.)


Takayuki Miki, Sho-hei Fujishima, Kazuhiro Komatsu, Keiko Kuwata, Shigeki Kiyonaka and Itaru Hamachi*, LDAI-based chemical labeling of intact membrane proteins and its pulse-chase analysis under live cell conditions. Chem. Biol. 2014, 21, 1013–1022.

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